MEDΦ / Team / Mateusz Rzycki
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Mateusz Rzycki

Researcher · PhD (2023)

Antimicrobials, bacterial membranes and AI-driven molecular design.

About

Mateusz Rzycki completed his PhD in 2023 in the MEDΦ group with a theoretical model that decomposes the antimicrobial effect into a physical, simulation-driven picture. He builds mimetic bacterial-envelope systems, including realistic E. coli models, and studies how surfactants and antiseptics act on them.

His recent work moves from analysis to design: generating new membrane-active antimicrobials with machine learning and testing them against specific bacterial microdomains. He is supported by a National Science Centre grant and co-develops numerical tools for membrane-interaction analysis.

Research interests

antimicrobialsbacterial membranesmolecular dynamicssurfactantsAI designDiptool

DONA

Recent publications

Latest five journal articles and book chapters

2026Journal article

Kryspin Mirota, Joanna Wicher-Żółtaniecka, Mateusz Rzycki, Izabela Popiel-Humeniuk, Andrzej Kosior, Ziemowit Ostrowski. Patient-specific continuous non-invasive blood pressure waveform in computed tomography derived fractional flow reserve calculation: Comparison with population-based pressure models. Computer Methods and Programs in Biomedicine 2026 vol. 284, art. 109449, s. 1-9.

2026Journal article

Mateusz Rzycki, Adam Gruda. Designing AI-generated antimicrobials for targeting bacterial microdomains. Scientific Reports 2026 vol. 16, art. 1708, s. 1-14.

2025Journal article

Ambili Ramanthrikkovil Variyam, Mateusz Rzycki, Ramesh Nandi, Alexei A Stuchebrukhov, Dominik Borek-Drabik, Nadav Amdursky. The role of lipid phase and temperature in proton barrier and proton migration on biological membranes. Chemical Science 2025 vol. 16, nr 12, s. 5194-5204.

2024Journal article

Ambili Ramanthrikkovil Variyam, Mateusz Rzycki, Anna Yucknovsky, Alexei A Stuchebrukhov, Dominik Borek-Drabik, Nadav Amdursky. Proton diffusion on the surface of mixed lipid membranes highlights the role of membrane composition. Biophysical Journal 2024 vol. 123, nr 24, s. 4200-4210.

2024Journal article

Mateusz Rzycki, Dominik Borek-Drabik. Multifaceted activity of fabimycin: insights from molecular dynamics studies on bacterial membrane models. Journal of Chemical Information and Modeling 2024 vol. 64, nr 10, s. 4204-4217.

DONA · saved list: 2026-10-09

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